Abstract: Impedance scaling approach presented in this paper is specially developed for teleoperation robot control to meet requirements to control robots and mechatronic systems with completely different dimensions and mechanic characteristics than the human operator. It is applied to the developed Ro-TeMiNa robot system with 6 DOF and to the mechatronic handling device with 3 DOF for micro and nano operations. The hybrid approach transferring operator motion and manipulation skills for control of the robot system for cell micro and nano manipulations is based on visual/haptic interface.